Seizure reduction through interneuron-mediated entrainment using low frequency optical stimulation
نویسندگان
چکیده
منابع مشابه
Tremor entrainment by patterned low-frequency stimulation.
High-frequency test stimulation for tremor suppression is a standard procedure for functional target localization during deep brain stimulation. This method does not work in cases where tremor vanishes intraoperatively, for example, due to general anaesthesia or due to an insertional effect. To overcome this difficulty, we developed a stimulation technique that effectively evokes tremor in a we...
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Introduction: In this study, the role of A1 adenosine receptors in improving the effect of Low-Frequency Electrical Stimulation (LFS) on seizure-induced hyperexcitability of hippocampal CA1 pyramidal neurons was investigated. Methods: A semi-rapid hippocampal kindling model was used to induce seizures in male Wistar rats. Examination of the electrophysiological properties of CA1 pyramidal neur...
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In the CA1 region of adult guinea pig hippocampal slices, long trains of theta frequency (5 Hz) stimulation produced a small enhancement of basal synaptic transmission but depressed the strength of synaptic transmission at synapses that had recently undergone long-term potentiation (LTP). Five hertz stimulation delivered immediately prior to high-frequency stimulation also inhibited the subsequ...
متن کاملVagus nerve stimulation for refractory epilepsy in children: More to VNS than seizure frequency reduction.
PURPOSE Vagus nerve stimulation (VNS) is used increasingly as adjunctive therapy for refractory epilepsy. Studies of VNS in children report mainly seizure frequency reduction as a measure of efficacy and clinical details are often scanty. We report our experience with VNS in children with refractory epilepsy and emphasize the positive effects of VNS in terms of seizure severity. METHODS We re...
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Epilepsy is a neurological syndrome where there is an abnormal, spontaneous, excessive, repetitive, synchronous firing of groups of neurons and affects 1-2% of the world population [1]. It does not follow any geographic barriers, gender, race or age-preferences [1]. It does however show a tendency to peak at early and later years of life [2]. Mankind has known it for centuries [3]. According to...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2015
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2015.04.001